Célle: Welcome - Stem Cells in Menstrual Blood

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Comparative Matrix for Menstrual Stromal Cells and Bone Marrow Mesenchymal Cells

Cell Characteristics	Célle (Menstrual Stromal Cells)	BM MSC (Bone Marrow Mesenchymal Cells)
Cell Collection Procedure	Non-invasive menstrual cup similar to insertion of a tampon	Harvest bone marrow in the OR mobilized adult peripheral blood
Cell Morphology	stromal, mesenchymal-like, spindle-shaped in culture	stromal, mesenchymal-like, spindle-shaped in culture (4)
Cell Surface Markers associated with mesenchymal cells	CD29, CD44, CD73, CD90, CD105, CD166 MHC I+ MHC II-	CD29, CD44, CD73, CD90, CD105, CD166 MHC I+ MHC II- (1)(3)
Markers associated with embryonic stem cells	SSEA-4, Oct-4	none
Differentiation capability	Neural, Cardiogenic, Chondrogenic, Adipogenic, Osteogenic	Chondrogenic, Adipogenic, Osteogenic (2)
MLR	Cells demonstarted a weak stimulatory response which suggests potential use in first-degree relatives	Do not elicit alloreactive lymphocyte proliferative responses (1)
Karotype	Normal karyotype	Normal Karyotye (3)

References:

Le Blanc K, Tammik C, Rosendahl K, Zetterberg E, & Ringdén O. (2003). HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells. Exp Hematol, 31(10), 890-896.
Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, et al. (1999). Multilineage potential of adult human mesenchymal stem cells. Science, 284(5411), 143-147.
Kern S, Eichler H, Stoeve J, Klüter H, Bieback, K. (2006). Comparative Analysis of Mesenchymal Stem Cells from Bone Marrow, Umbilical Cord Blood, or Adipose Tissue. Stem Cells, 24(5), 1294 –1301.
Horwitz, Edwin M. (2007). Report on the Workshop "New Technologies in Stem Cell Research," Society for Pediatric Research, San Francisco, California, April 29, 2006, Fundamentals of MSC Isolation and Purification.Stem Cells, 25(4), 1070 -1088.
Schachinger V, Erbs S, Elsasser A, Haberbosch W, Hambrecht R, et al. (2006). Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N Engl J Med, 355(12), 1210-1221.
Horwitz EM, Prockop DJ, Fitzpatrick LA, Koo WW, Gordon PL, et al. (1999). Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat Med, 5, 309–313.